Abnormalities in the cyclic adenosine monophosphate (cAMP)-dependent phosphorylation system have been recently reported in patients with bipolar disorder. We evaluated the immunoreactivity of the regulatory and catalytic subunits of cAMP-dependent protein kinase (protein kinase A) and 1 of its substrates, Rap1, in platelets from untreated euthymic, manic, and depressed patients with bipolar disorder and healthy subjects.
|Titolo:||Abnormalities of cyclic adenosine monophosphate signaling in platelets from untreated patients with bipolar disorder|
|Data di pubblicazione:||1999|
|Appare nelle tipologie:||1.1 Articolo in rivista|